Dosing should occur either > 2 hours before or > 4 hours after administration of a bile acid sequestrant. Simvastatin is effective alone or in combination with bile acid sequestrants. Adjustments of dosage, if required, should be made as specified above. Drug therapy can be initiated simultaneously with diet and exercise. The usual dose of Simvastatin is 20 to 40 mg/day given as a single dose in the evening in patients at high risk of coronary heart disease (CHD, with or without hyperlipidaemia). In patients taking lomitapide concomitantly with Simvastatin, the dose of simvastain must not exceed 40 mg/day (see sections 4.3, 4.4 and 4.5). LDL-apheresis) in these patients or if such treatments are unavailable. Homozygous familial hypercholesterolaemiaīased on the results of a controlled clinical study, the recommended simvastatin dose is 40 mg/day in the evening Simvastatin should be used as an adjunct to other lipid-lowering treatments (e.g. Patients who require a large reduction in LDL-C (more than 45%) may be started at 20-40-mg/ day given as a single dose in the evening. The usual starting dose is 10-20 mg/day given as a single dose in the evening. The patient should be placed on a standard cholesterol-lowering diet, and should continue with this diet during treatment with Simvastatin. The 80 mg dose is only recommended in patients with severe hypercholesterolaemia and high risk for cardiovascular complications who have not achieved their treatment goals on lower doses and when the benefits are expected to outweigh the potential risks (see sections 4.4 and 5.1). Adjustments of dosage, if required, should be made at intervals of not less than 4 weeks, to a maximum of 80 mg/day given as a single dose in the evening. The dosage range is 5-80 mg/day given orally as a single dose in the evening. Date of first authorisation/renewal of the authorisation 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.4.2 Posology and method of administration.In rare cases, it’s possible to have a serious allergic reaction ( anaphylaxis) to simvastatin.Show table of contents Hide table of contents you have a cough, feel short of breath, and have lost weight – this can be a sign of lung disease.you have severe stomach pain – this can be a sign of acute pancreatitis.
#Simvastatin 20 mg side effect skin#
you get a skin rash with pink-red blotches, especially on the palms of your hands or soles of your feet – this could be a sign of the skin reaction, erythema multiforme.the whites of your eyes turn yellow, or your skin turns yellow (although this may be less obvious on brown or black skin), or if you have pale poo and dark pee – this can be signs of liver problems.you get unexplained muscle pain, tenderness, weakness or cramps (this is more likely if you’re taking a higher dose of simvastatin, and it can happen a few weeks or months after you first start taking this medicine) – this can be signs of muscle breakdown and kidney damage.Stop taking simvastatin and call a doctor or contact 111 if: It happens rarely, but less than 1 in 1,000 people taking simvastatin may have a serious side effect. They may recommend trying a lower dose of simvastatin, or a different statin. Talk to your doctor or pharmacist if you do get any side effects and they bother you, or do not go away. Like all medicines, simvastatin can cause side effects in some people, but not everybody gets them.
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